Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.36 |
| ▸ | MEN1 | O00255 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.36 |
| ▸ | USP2 | O75604 | 5/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358968 | 0.75 | ADORA1 (0.34) | ADORA1TMIGD3ADORA2A | |
| SCHEMBL2369044 | 0.68 | MCL1 (0.34) | ADORA1TMIGD3CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3384503 | 0.68 | MCL1 (0.36) | CYP2C19MEN1KMT2AALOX15ALDH1A1 | |
| SCHEMBL3384508 | 0.67 | SMN1; SMN2 (0.58) | CYP1A2CYP3A4CYP2C19CYP2D6MEN1 | |
| SCHEMBL2368933 | 0.61 | MAPK1 (0.44) | MEN1KMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL27386212 | 0.60 | SELE (0.36) | CYP1A2ALDH1A1CYP2C9TSHRLMNA | |
| SCHEMBL29619599 | 0.59 | CYP1A2 (0.42) | CYP1A2CYP3A4CYP2C19CYP2D6MEN1 | |
| SCHEMBL2369352 | 0.58 | ATM (0.37) | MEN1KMT2AALDH1A1USP2HSD17B10 | |
| SCHEMBL2056343 | 0.58 | CYP1A2 (0.39) | ADORA1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL2716516 | 0.57 | CYP11B1 (0.59) | ADORA1CYP1A2CYP3A4CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |