Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368844 | 0.77 | ALDH1A1 (0.40) | HTTSMN1; SMN2NPSR1POLBPIP4K2C | |
| SCHEMBL5804191 | 0.75 | FGFR1 (0.56) | HTTSMN1; SMN2POLBPIP4K2CTP53 | |
| SCHEMBL3385254 | 0.75 | PIP4K2C (0.35) | HTTSMN1; SMN2NPSR1POLBPIP4K2C | |
| SCHEMBL3385257 | 0.72 | TNF (0.61) | HTTSMN1; SMN2NPSR1POLBPIP4K2C | |
| SCHEMBL2369147 | 0.70 | MAPT (0.49) | HTTSMN1; SMN2NPSR1POLBPIP4K2C | |
| SCHEMBL2369456 | 0.67 | NPSR1 (0.37) | HTTSMN1; SMN2NPSR1POLBPIP4K2C | |
| SCHEMBL2369434 | 0.64 | PIP4K2C (0.35) | HTTSMN1; SMN2NPSR1POLBPIP4K2C | |
| SCHEMBL2369895 | 0.63 | ATM (0.37) | HTTSMN1; SMN2TNFMAPK1NOD1 | |
| SCHEMBL2369144 | 0.60 | CAMKK1 (0.36) | HTTSMN1; SMN2PIP4K2CKMT2AESR1 | |
| SCHEMBL2368832 | 0.60 | GAA (0.52) | HTTSMN1; SMN2NPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |