Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 5/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.32 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369434 | 0.81 | PIP4K2C (0.35) | PIP4K2CHTTNPSR1SMN1; SMN2POLB | |
| SCHEMBL2368686 | 0.78 | EGFR (0.37) | PIP4K2CHTTSMN1; SMN2POLBLMNA | |
| SCHEMBL2369059 | 0.75 | FGFR1 (0.56) | HTTSMN1; SMN2LMNAHPGDGPR55 | |
| SCHEMBL2368844 | 0.75 | ALDH1A1 (0.40) | PIP4K2CHTTNPSR1SMN1; SMN2POLB | |
| SCHEMBL2369167 | 0.75 | HTT (0.37) | PIP4K2CHTTNPSR1SMN1; SMN2POLB | |
| SCHEMBL3385743 | 0.72 | HTT (0.54) | PIP4K2CHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL3387950 | 0.72 | LMNA (0.52) | PIP4K2CHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL3382727 | 0.70 | KDR (0.41) | PIP4K2CHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL3385257 | 0.70 | TNF (0.61) | PIP4K2CHTTNPSR1SMN1; SMN2POLB | |
| SCHEMBL3381240 | 0.70 | LMNA (0.48) | PIP4K2CHTTNPSR1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |