Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368964 | 0.78 | MAPT (0.34) | SMN1; SMN2MRGPRX1LIMK1MEN1KMT2A | |
| SCHEMBL6359806 | 0.76 | SMN1; SMN2 (0.39) | ATMHTTSMN1; SMN2LIMK1NPC1 | |
| SCHEMBL5804191 | 0.75 | FGFR1 (0.56) | HTTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL3382775 | 0.73 | EGFR (0.36) | ATMHTTSMN1; SMN2MRGPRX1LIMK1 | |
| SCHEMBL14965012 | 0.73 | SMN1; SMN2 (0.42) | HTTSMN1; SMN2MRGPRX1LIMK1MEN1 | |
| SCHEMBL3382778 | 0.70 | TNF (0.61) | HTTSMN1; SMN2RAB9ATNFMAPK1 | |
| SCHEMBL5792474 | 0.66 | PTGS1 (0.43) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL3387010 | 0.63 | LIMK1 (0.34) | HTTSMN1; SMN2MRGPRX1LIMK1MEN1 | |
| SCHEMBL2369167 | 0.63 | HTT (0.37) | ATMHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2369352 | 0.62 | ATM (0.37) | ATMSMN1; SMN2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |