Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.59 |
| ▸ | FAAH | O00519 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39140 | 0.98 | HPGD (0.61) | GABRA1HPGDCYP3A4GABRB1LMNA | |
| SCHEMBL31011017 | 0.98 | HPGD (0.61) | GABRA1HPGDCYP3A4GABRB1LMNA | |
| SCHEMBL20853605 | 0.86 | GABRA1 (0.61) | GABRA1HPGDCYP3A4GABRB1LMNA | |
| Propofol SCHEMBL4023094 | 0.86 | GABRA1 (0.81) | GABRA1HPGDCYP3A4GABRB1LMNA | |
| SCHEMBL1039957 | 0.85 | ALDH1A1 (0.55) | GABRA1HPGDCYP3A4GABRB1LMNA | |
| SCHEMBL2164384 | 0.84 | HPGD (0.46) | GABRA1HPGDCYP3A4GABRB1LMNA | |
| SCHEMBL31123826 | 0.84 | GABRA1 (0.64) | GABRA1HPGDCYP3A4GABRB1LMNA | |
| SCHEMBL8680640 | 0.84 | GABRA1 (0.64) | GABRA1HPGDCYP3A4GABRB1LMNA | |
| SCHEMBL10603918 | 0.83 | ALDH1A1 (0.53) | GABRA1HPGDCYP3A4GABRB1LMNA | |
| SCHEMBL29484676 | 0.82 | GABRA1 (0.61) | GABRA1HPGDCYP3A4GABRB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210371609-A1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | COVESTRO LLC | 2021-12-02 | — | — | US | disclosed |
| EP-3707198-B1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | COVESTRO DEUTSCHLAND AG (DE) | 2021-10-27 | — | — | EP | disclosed |
| EP-3707198-A1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | Covestro Deutschland AG (DE) | 2020-09-16 | — | — | EP | disclosed |
| US-10131178-B2 | Layered structure and films for ID documents having improved properties for laser engraving | COVESTRO DEUTSCHLAND AG (DE) | 2018-11-20 | — | — | US | disclosed |
| EP-2820071-B1 | PROCESS FOR THE PRODUCTION OF LOW STRESS AND OPTICAL QUALITY FILM FOR USE IN OPTO-ELECTRONIC DEVICES | COVESTRO DEUTSCHLAND AG (DE) | 2017-03-22 | — | — | EP | disclosed |
| EP-2820071-A1 | PROCESS FOR THE PRODUCTION OF LOW STRESS AND OPTICAL QUALITY FILM FOR USE IN OPTO-ELECTRONIC DEVICES | Bayer Intellectual Property GmbH (DE) | 2015-01-07 | — | — | EP | disclosed |
| WO-2013127851-A1 | PROCESS FOR THE PRODUCTION OF LOW STRESS AND OPTICAL QUALITY FILM FOR USE IN OPTO-ELECTRONIC DEVICES | BAYER MATERIALSCIENCE AG (DE) | 2013-09-06 | — | — | WO | disclosed |
| EP-2634208-A1 | Process for the production of low stress and optical quality film for use in opto-electronic devices | Bayer MaterialScience AG (DE) | 2013-09-04 | — | — | EP | disclosed |
| US-20120001413-A1 | LAYER STRUCTURE AND FILMS FOR ID DOCUMENTS HAVING IMPROVED PROPERTIES FOR LASER ENGRAVING | BAYER MATERIALSCIENCE AG (DE) | 2012-01-05 | — | — | US | disclosed |
| US-20110193337-A1 | FORGERY-PROOF SECURITY FEATURES IN SECURITY OR VALUE DOCUMENTS | BAYER MATERIAL SCIENCE AG (DE) | 2011-08-11 | — | — | US | disclosed |
| US-7250483-B2 | Inhibition of catalytically active impurities in polycarbonate by the melt transesterification process | BAYER MATERIALSCIENCE AG (DE) | 2007-07-31 | — | — | US | disclosed |
| US-7091302-B2 | Process for the preparation of polycarbonate | BAYER MATERIALSCIENCE AG (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20060004178-A1 | Inhibition of catalytically active impurities in polycarbonate by the melt transesterification process | COVESTRO DEUTSCHLAND AG (DE) | 2006-01-05 | — | — | US | disclosed |
| US-20050239995-A1 | Process for the preparation of polycarbonate | BAYER MATERIALSCIENCE AG | 2005-10-27 | — | — | US | disclosed |