Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | SLC26A6 | Q9BXS9 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415878 | 0.92 | ESR1 (0.44) | ESR1ALDH1A1LMNARXFP1KDM4E | |
| Butane SCHEMBL6359950 | 0.90 | ESR1 (0.38) | ESR1ALDH1A1HPGDLMNARXFP1 | |
| SCHEMBL3386697 | 0.89 | TNF (0.48) | PTPN1ESR1MAPTALDH1A1KDM4E | |
| SCHEMBL2369294 | 0.88 | TGM2 (0.36) | PTPN1ESR1MAPTALDH1A1HPGD | |
| SCHEMBL2368960 | 0.86 | ESR1 (0.39) | ESR1ALDH1A1HPGDLMNARXFP1 | |
| SCHEMBL3383460 | 0.85 | PRKCZ (0.43) | PRKCZMAPTALDH1A1HPGDLMNA | |
| SCHEMBL3384941 | 0.85 | ALDH1A1 (0.38) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL2369471 | 0.85 | ALDH1A1 (0.47) | PRKCZESR1MAPTALDH1A1HPGD | |
| SCHEMBL2368543 | 0.82 | TNF (0.56) | ESR1ALDH1A1LMNASMN1; SMN2TNF | |
| SCHEMBL3415890 | 0.80 | ESR1 (0.40) | ESR1ALDH1A1LMNASMN1; SMN2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |