Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368933 | 0.81 | MAPK1 (0.44) | ATMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14964976 | 0.75 | L3MBTL1 (0.34) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL29915072 | 0.70 | NOTUM (0.37) | L3MBTL1 | |
| SCHEMBL27002529 | 0.70 | NOTUM (0.37) | L3MBTL1 | |
| SCHEMBL14965012 | 0.70 | SMN1; SMN2 (0.42) | ALDH1A1MEN1KMT2APOLBHPGD | |
| SCHEMBL14964882 | 0.68 | FGFR1 (0.53) | ATMALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL29915194 | 0.68 | EGFR (0.30) | EGFR | |
| SCHEMBL2859453 | 0.68 | ALDH1A1 (0.43) | ALDH1A1KDM4EKMT2AMAPK1MAPT | |
| SCHEMBL3038100 | 0.67 | GPR3 (0.48) | ALDH1A1KDM4EEGFRMEN1KMT2A | |
| SCHEMBL29717311 | 0.67 | GPR3 (0.48) | ALDH1A1KDM4EEGFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |