Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | CDC25C | P30307 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1505957 | 0.87 | HPGDS (0.42) | DGAT1CYP2C9CYP2C19CYP2E1CYP3A4 | |
| SCHEMBL4069982 | 0.85 | HPGDS (0.41) | DGAT1CYP2C9CYP2C19CYP2E1CYP3A4 | |
| SCHEMBL24229626 | 0.82 | CYP2E1 (0.38) | DGAT1CYP2C9CYP2C19CYP2E1CYP3A4 | |
| SCHEMBL29019769 | 0.82 | DGAT1 (0.34) | DGAT1CYP2C9CYP2C19CYP2E1CYP3A4 | |
| SCHEMBL4065195 | 0.82 | MAPT (0.48) | CYP11B1DGAT1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL31106991 | 0.81 | HSD17B1 (0.41) | CYP2C9CYP2C19CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL24955615 | 0.81 | HSD17B1 (0.41) | CYP2C9CYP2C19CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL31403194 | 0.81 | DGAT1 (0.39) | CYP11B1CYP11B2DGAT1SMN1; SMN2CYP2C9 | |
| SCHEMBL4062141 | 0.80 | DGAT1 (0.38) | CYP11B1CYP11B2CYP1A2DGAT1SMN1; SMN2 | |
| SCHEMBL204155 | 0.80 | SMN1; SMN2 (0.46) | CYP1A2DGAT1SMN1; SMN2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026265-B2 | Heterocycle substituted ketone derivatives as histone deacetylase (HDAC) inhibitors | Istituto de Ricerche di Biologia Molecolare P. Angeletti SpA. (IT) | 2011-09-27 | — | — | US | disclosed |
| US-20100234374-A1 | Heterocycle Substituted Ketone Derivatives as Histone Deacetylase (HDAC) Inhibitors | MSD ITALIA S.R.L. (IT) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234374-A1 | Heterocycle Substituted Ketone Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC1, HDAC7, HDAC4 | CYP11B1 282/4885CYP11B2 441/4885CDC25A 2454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.