Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.37 |
| ▸ | EIF4E | P06730 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14321882 | 0.89 | MKNK1 (0.36) | FGFR1FGFR4MKNK1EIF4EKCNH2 | |
| SCHEMBL12294123 | 0.89 | MMP13 (0.41) | — | |
| SCHEMBL12294349 | 0.85 | KDM1A (0.39) | MKNK1 | |
| Hydrochloric Acid SCHEMBL14321309 | 0.84 | KDM1A (0.39) | MKNK1 | |
| SCHEMBL2369606 | 0.77 | FNTA (0.36) | — | |
| SCHEMBL2369377 | 0.77 | MKNK1 (0.42) | MKNK1EIF4EKCNH2MKNK2NPC1 | |
| SCHEMBL12295346 | 0.74 | SLC2A1 (0.42) | MKNK1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14321953 | 0.66 | FNTA (0.39) | SMN1; SMN2 | |
| SCHEMBL14321883 | 0.65 | MKNK1 (0.38) | MKNK1EIF4EKCNH2MKNK2NPC1 | |
| SCHEMBL2369204 | 0.65 | MET (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | OSI Pharmaceuticals,. LLC | 2012-12-27 | — | — | US | disclosed |
| WO-2011109593-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | OSI Pharmaceuticals, LLC (US) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | MET, KRAS, VHL | FGFR1 146/4885FGFR4 232/4885MKNK1 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.