Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12294349 | 0.78 | KDM1A (0.39) | MKNK1 | |
| Hydrochloric Acid SCHEMBL14321309 | 0.77 | KDM1A (0.39) | MKNK1 | |
| SCHEMBL2369372 | 0.74 | FGFR1 (0.38) | ALDH1A1HPGDSMN1; SMN2MKNK1ADK | |
| SCHEMBL2369583 | 0.72 | SLC2A1 (0.49) | SLC2A1CYP11B1KLKB1KLK1KMT2A | |
| SCHEMBL12294123 | 0.71 | MMP13 (0.41) | KDM4EHTR6 | |
| SCHEMBL14321882 | 0.71 | MKNK1 (0.36) | ALDH1A1HPGDSMN1; SMN2MKNK1NPC1 | |
| SCHEMBL14321740 | 0.70 | KDM4E (0.48) | CYP11B1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL12293746 | 0.69 | ADRA2A (0.47) | KDM4EALDH1A1HPGDHSD17B10ADORA2A | |
| SCHEMBL17981498 | 0.68 | ADORA2A (0.40) | ALDH1A1ADORA2AHTR6ADKHTR1A | |
| SCHEMBL17981147 | 0.68 | ADORA2A (0.47) | ALDH1A1ADORA2AMKNK1HTR6ADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | OSI Pharmaceuticals,. LLC | 2012-12-27 | — | — | US | disclosed |
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | OSI Pharmaceuticals,. LLC | 2012-12-27 | — | — | US | disclosed |
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | OSI Pharmaceuticals,. LLC | 2012-12-27 | — | — | US | disclosed |
| WO-2011109593-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | OSI Pharmaceuticals, LLC (US) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | MET, KRAS, VHL | SLC2A1 193/4885CYP11B1 77/4885KDM4E 2706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.