Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21017126 | 0.98 | ALOX12 (0.48) | ALOX12TLR8HTTSMN1; SMN2TLR7 | |
| SCHEMBL19852711 | 0.98 | ALOX12 (0.48) | ALOX12TLR8HTTSMN1; SMN2TLR7 | |
| SCHEMBL23612390 | 0.98 | ALOX12 (0.45) | ALOX12TLR8HTTSMN1; SMN2TLR7 | |
| SCHEMBL23768097 | 0.98 | ALOX12 (0.48) | ALOX12TLR8HTTSMN1; SMN2TLR7 | |
| SCHEMBL22436194 | 0.91 | ALOX12 (0.44) | ALOX12TLR8HTTSMN1; SMN2TLR7 | |
| SCHEMBL23812304 | 0.89 | HTT (0.44) | ALOX12TLR8HTTSMN1; SMN2TLR7 | |
| SCHEMBL19352969 | 0.86 | ALOX12 (0.48) | ALOX12TLR8HTTSMN1; SMN2TLR7 | |
| SCHEMBL23720420 | 0.86 | ALOX12 (0.48) | ALOX12TLR8HTTSMN1; SMN2TLR7 | |
| SCHEMBL23697921 | 0.81 | TLR8 (0.44) | ALOX12TLR8HTTSMN1; SMN2TLR7 | |
| SCHEMBL11985605 | 0.80 | HTT (0.40) | ALOX12TLR8HTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300941-A1 | BISPECIFIC DEGRADERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-20210228549-A1 | RILUZOLE PRODRUGS AND THEIR USE | BEETLEJUICE SA LLC, AS PURCHASER AGENT | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300941-A1 | BISPECIFIC DEGRADERS | CRBN, IDE, PSEN2 | ALOX12 4363/4885TLR8 4486/4885HTT 214/4885 |
| US-20210228549-A1 | RILUZOLE PRODRUGS AND THEIR USE | APEH, ALDH1A2, UGT1A9 | ALOX12 821/4885TLR8 4322/4885HTT 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.