Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24903821 | 0.76 | MAPT (0.41) | MAPTEPHX2L3MBTL1KDM4EKIF11 | |
| SCHEMBL23848246 | 0.75 | KIF11 (0.44) | MAPTEPHX2KIF11RAB9ANPC1 | |
| SCHEMBL31212781 | 0.73 | MAPT (0.61) | MAPTEPHX2L3MBTL1KDM4EKIF11 | |
| SCHEMBL3194551 | 0.73 | MAPT (0.61) | MAPTEPHX2L3MBTL1KDM4EKIF11 | |
| SCHEMBL31212780 | 0.73 | MAPT (0.61) | MAPTEPHX2L3MBTL1KDM4EKIF11 | |
| SCHEMBL1923201 | 0.73 | MAPT (0.61) | MAPTEPHX2L3MBTL1KDM4EKIF11 | |
| SCHEMBL29087276 | 0.72 | KIF11 (0.40) | MAPTEPHX2KIF11RAB9AKMT2A | |
| SCHEMBL254957 | 0.72 | MAPT (0.56) | MAPTEPHX2L3MBTL1KDM4EKIF11 | |
| SCHEMBL10492306 | 0.71 | MAPT (0.53) | MAPTEPHX2L3MBTL1KDM4EKIF11 | |
| SCHEMBL18500607 | 0.70 | MAPT (0.57) | MAPTEPHX2L3MBTL1KDM4EKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188949-A1 | 3-DIARYLMETHYLENES AND USES THEREOF | ATUX ISKAY LLC (US) | 2021-09-23 | — | — | WO | disclosed |
| WO-2021150697-A1 | N-SUBSTITUTED-3-TRICYCLYL PIPERIDINE DERIVATIVES AS ANTICANCER AND NEUROPROTECTIVE AGENTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-07-29 | — | — | WO | disclosed |