Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 4/20 | 0.57 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.57 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.57 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806259 | 0.81 | ABCC9 (0.59) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL1806258 | 0.81 | ABCC9 (0.59) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL20194455 | 0.81 | KCNJ11 (0.59) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL30640474 | 0.81 | KCNJ11 (0.59) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL8899556 | 0.78 | ABCC9 (0.55) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL7746823 | 0.78 | ABCC9 (0.56) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL2889109 | 0.78 | KCNJ11 (0.56) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL8628219 | 0.77 | KCNJ11 (0.62) | KCNJ11ABCC9ABCC8KCNJ8RXFP1 | |
| SCHEMBL23499928 | 0.77 | MTNR1A (0.56) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL9486801 | 0.77 | KCNJ11 (0.48) | KCNJ11ABCC9ABCC8KCNJ8RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110105165-A | A kind of preparation method of high-purity 1,4- dibromine naphthalene | 黑龙江省科学院石油化学研究院 | 2019-08-09 | — | — | CN | claimed |
| EP-3044284-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-11-13 | — | — | EP | disclosed |
| EP-3044284-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-11-13 | — | — | EP | disclosed |
| CN-110105165-A | A kind of preparation method of high-purity 1,4- dibromine naphthalene | 黑龙江省科学院石油化学研究院 | 2019-08-09 | — | — | CN | disclosed |
| CN-105531347-B | Metal complex | 默克专利有限公司 | 2018-09-11 | — | — | CN | disclosed |
| US-9831448-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-11-28 | — | — | US | disclosed |
| US-9831448-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-11-28 | — | — | US | disclosed |
| US-9831448-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-11-28 | — | — | US | disclosed |
| US-20160233443-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | US | disclosed |
| US-20160233443-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | US | disclosed |
| US-20160233443-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | US | disclosed |
| EP-3044284-A1 | METAL COMPLEXES | Merck Patent GmbH (DE) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036074-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2015-03-19 | — | — | WO | disclosed |
| WO-2015036074-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2015-03-19 | — | — | WO | disclosed |
| EP-2755982-A1 | SILYL-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | Merck Sharp & Dohme Corp. (US) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013039878-A1 | SILYL-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2013-03-21 | — | — | WO | disclosed |
| EP-2545060-A1 | FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112429-A1 | FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | SCHERING CORPORATION (US) | 2011-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160233443-A1 | Metal Complexes | AP1M1, SOD1, AP3M1 | KCNJ11 256/4885ABCC9 2307/4885ABCC8 3795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.