Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30678550 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL31115435 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL28947251 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL23698910 | 0.84 | KDM4E (0.38) | KDM4EALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL19126021 | 0.83 | ALDH1A1 (0.39) | KDM4EALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL31417692 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL23698350 | 0.82 | AKR1C3 (0.43) | KDM4ESMN1; SMN2XDHPTPN1MAPT | |
| SCHEMBL31417774 | 0.81 | KDM4E (0.36) | KDM4EALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL31417569 | 0.81 | KDM4E (0.36) | KDM4EALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL22032138 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1KMT2AHPGDCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12162864-B2 | Condensed-cyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-12-10 | — | — | US | disclosed |
| US-12012419-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-06-18 | — | — | US | disclosed |
| CN-112752760-B | Heterocyclic compounds | 武田药品工业株式会社 | 2024-01-19 | — | — | CN | disclosed |
| US-20210347786-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-11-11 | — | — | US | disclosed |
| EP-3858838-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2021-08-04 | — | — | EP | disclosed |
| EP-3858823-A1 | CONDENSED-CYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2021-08-04 | — | — | EP | disclosed |
| CN-112752760-A | Heterocyclic compounds | 武田药品工业株式会社 | 2021-05-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210347786-A1 | HETEROCYCLIC COMPOUND | SLC10A2, ALPI, SLC10A1 | KDM4E 2171/4885ALDH1A1 177/4885SOS1 1176/4885 |
| US-12012419-B2 | Heterocyclic compound | SLC10A2, ALPI, SLC10A1 | KDM4E 2171/4885ALDH1A1 177/4885SOS1 1176/4885 |
| US-12162864-B2 | Condensed-cyclic compound | SLC10A2, VIP, AVPR2 | KDM4E 2962/4885ALDH1A1 1810/4885SOS1 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.