Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370870 | 0.81 | ITK (0.48) | RAB9AMAPTGAACYP1A2CYP3A4 | |
| SCHEMBL2370873 | 0.81 | ITK (0.48) | RAB9AMAPTGAACYP1A2CYP3A4 | |
| SCHEMBL2370319 | 0.81 | LMNA (0.42) | RAB9AMAPTGAACYP1A2CYP3A4 | |
| SCHEMBL2370005 | 0.80 | RAB9A (0.51) | RAB9AMAPTGAACYP1A2CYP3A4 | |
| SCHEMBL2369866 | 0.79 | AURKB (0.46) | RAB9AMAPTGAACYP1A2CYP3A4 | |
| SCHEMBL2370335 | 0.78 | ALDH1A1 (0.45) | RAB9AMAPTGAACYP3A4KMT2A | |
| SCHEMBL2370982 | 0.74 | RAB9A (0.53) | RAB9AMAPTGAACYP1A2CYP3A4 | |
| SCHEMBL2369553 | 0.72 | RAB9A (0.46) | RAB9AMAPTGAACYP1A2CYP3A4 | |
| SCHEMBL2370449 | 0.70 | GAA (0.58) | MAPTGAAMEN1KMT2AHDAC1 | |
| SCHEMBL29470520 | 0.70 | LCK (0.54) | RAB9AMAPTGAACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |