Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30123443 | 0.69 | SNCA (0.49) | GAAMAPTKMT2ALMNATSHR | |
| SCHEMBL29219009 | 0.69 | SNCA (0.43) | GAAMAPTKMT2AMEN1LMNA | |
| SCHEMBL18380100 | 0.62 | KEAP1 (0.67) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11221556 | 0.62 | IDO1 (0.50) | GAAMAPTKMT2AMEN1LMNA | |
| SCHEMBL5949996 | 0.61 | TDP1 (0.40) | GAAMAPTKMT2AMEN1LMNA | |
| SCHEMBL22206166 | 0.61 | NPC1 (0.55) | MAPTKMT2AMEN1LMNATSHR | |
| SCHEMBL29838394 | 0.61 | NPC1 (0.55) | MAPTKMT2AMEN1LMNATSHR | |
| SCHEMBL3042154 | 0.61 | LMNA (0.57) | GAALMNAALDH1A1SNCATDP1 | |
| Dinitrophenylene SCHEMBL7647705 | 0.60 | TSHR (0.90) | GAAKMT2ALMNATSHRALDH1A1 | |
| SCHEMBL10913298 | 0.60 | HSD17B10 (0.56) | GAAMAPTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |