Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12291456 | 0.83 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL2370616 | 0.81 | ITK (0.57) | POLBITKLCKAURKBSSTR5 | |
| SCHEMBL2370622 | 0.81 | ITK (0.57) | POLBITKLCKAURKBSSTR5 | |
| SCHEMBL807801 | 0.81 | LMNA (0.42) | POLBLMNAL3MBTL1LCKTNIK | |
| SCHEMBL2370319 | 0.81 | LMNA (0.42) | NPC1RAB9ALMNAL3MBTL1LCK | |
| SCHEMBL2369709 | 0.80 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL10285818 | 0.79 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2POLBITK | |
| SCHEMBL798710 | 0.78 | LCK (0.45) | NPC1RAB9ASMN1; SMN2POLBITK | |
| SCHEMBL2370454 | 0.78 | ITK (0.53) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL2370453 | 0.77 | ITK (0.45) | NPC1RAB9ASMN1; SMN2POLBITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |