Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24019194 | 0.88 | KDR (0.44) | LCKRAB9AKDRNPC1SMN1; SMN2 | |
| SCHEMBL2398991 | 0.82 | ITK (0.57) | LCKKDRSSTR5ITKAURKB | |
| SCHEMBL2398982 | 0.82 | ITK (0.57) | LCKKDRSSTR5ITKAURKB | |
| SCHEMBL2369709 | 0.80 | NPC1 (0.52) | LCKRAB9ANPC1SMN1; SMN2SSTR5 | |
| SCHEMBL10286645 | 0.79 | ITK (0.44) | LCKKDRSSTR5ITKAURKB | |
| SCHEMBL2370127 | 0.78 | NPC1 (0.44) | LCKRAB9ANPC1SMN1; SMN2SSTR5 | |
| SCHEMBL10285818 | 0.77 | NPC1 (0.49) | LCKRAB9ANPC1SMN1; SMN2SSTR5 | |
| SCHEMBL2370220 | 0.77 | ALDH1A1 (0.59) | LCKRAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL807804 | 0.75 | LCK (0.46) | LCKRAB9AKDRNPC1SMN1; SMN2 | |
| SCHEMBL807541 | 0.75 | ITK (0.55) | LCKSSTR5ITKAURKBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |