Sugi Predict

Sugi Predict / Compounds / SCHEMBL23705771

SCHEMBL23705771

SCHEMBL23705771

Clc1cc2cc(-c3ccccc3)ccc2cn1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CLK4 Q9HAZ1 2/20 0.51
▸ MAP4K4 O95819 2/20 0.51
▸ TYK2 P29597 2/20 0.51
▸ MINK1 Q8N4C8 1/20 0.51
▸ SRPK1 Q96SB4 1/20 0.51
▸ ESR2 Q92731 3/20 0.47
▸ ESR1 P03372 2/20 0.47
▸ BACE1 P56817 1/20 0.43
▸ FGFR1 P11362 1/20 0.43
▸ DYRK3 O43781 1/20 0.43
▸ CLK1 P49759 1/20 0.43
▸ CLK2 P49760 1/20 0.43
▸ CLK3 P49761 1/20 0.43
▸ GSK3B P49841 1/20 0.43
▸ CDK5 Q00535 1/20 0.43
▸ DYRK1A Q13627 1/20 0.43
▸ CDK5R1 Q15078 1/20 0.43
▸ DYRK2 Q92630 1/20 0.43
▸ DYRK1B Q9Y463 1/20 0.43
▸ CYP11B1 P15538 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32682142 0.93 ESR1 (0.48) CLK4MAP4K4TYK2MINK1SRPK1
SCHEMBL16968057 0.84 DYRK1A (0.52) CLK4MAP4K4TYK2CLK1CLK2
SCHEMBL15507438 0.83 CYP2A6 (0.62) CLK4MAP4K4MINK1FGFR1DYRK3
SCHEMBL15507390 0.81 ABL1 (0.44) CLK4MAP4K4TYK2MINK1FGFR1
SCHEMBL30041837 0.78 NPC1 (0.50) GSK3BNPC1RAB9A
SCHEMBL21767440 0.78 CLK4 (0.51) CLK4MAP4K4TYK2MINK1SRPK1
SCHEMBL21782906 0.78 CLK4 (0.51) CLK4MAP4K4TYK2MINK1SRPK1
SCHEMBL23705954 0.78 NPC1 (0.50) GSK3BNPC1RAB9A
SCHEMBL30502940 0.78 CYP2A6 (0.54) NPC1RAB9ACYP1A2
SCHEMBL239390 0.78 CYP2A6 (0.54) NPC1RAB9ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12441726-B2 Compounds and uses thereof FOGHORN THERAPEUTICS, INC. (US) 2025-10-14 — — US disclosed
CN-115297861-B Compounds and uses thereof 福宏治疗公司 2024-07-12 — — CN disclosed
US-20230145003-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2023-05-11 — — US disclosed
US-20230145003-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2023-05-11 — — US disclosed
US-20230145003-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2023-05-11 — — US disclosed
EP-4096667-A1 COMPOUNDS AND USES THEREOF Foghorn Therapeutics Inc. (US) 2022-12-07 — — EP disclosed
CN-115297861-A Compound and use thereof 福宏治疗公司 2022-11-04 — — CN disclosed
WO-2021155320-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. (US) 2021-08-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12441726-B2 Compounds and uses thereof VHL, CLN6, TFEB CLK4 3581/4885MAP4K4 3227/4885TYK2 2511/4885
US-20230145003-A1 COMPOUNDS AND USES THEREOF VHL, CLN6, TFEB CLK4 3581/4885MAP4K4 3227/4885TYK2 2511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.