Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM4B | O94953 | 2/20 | 0.48 |
| ▸ | KDM5C | P41229 | 2/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23706062 | 0.82 | ACACB (0.48) | KDM4AKDM4BKDM5CKDM5BSMN1; SMN2 | |
| SCHEMBL509374 | 0.79 | KDM5B (0.50) | KDM4AKDM4BKDM5CKDM5BSMN1; SMN2 | |
| SCHEMBL23706030 | 0.77 | CYP1A2 (0.39) | KDM4AKDM4BKDM5CKDM5BSMN1; SMN2 | |
| SCHEMBL23705944 | 0.75 | NR3C2 (0.55) | KDM4AKDM4BKDM5CKDM5BSMN1; SMN2 | |
| SCHEMBL22581521 | 0.73 | KMT2A (0.49) | SMN1; SMN2KMT2ANPC1RAB9AHPGD | |
| SCHEMBL243740 | 0.73 | SMN1; SMN2 (0.76) | SMN1; SMN2GAAKMT2ANPC1RAB9A | |
| SCHEMBL30602600 | 0.73 | SMN1; SMN2 (0.76) | SMN1; SMN2GAAKMT2ANPC1RAB9A | |
| SCHEMBL21437557 | 0.72 | RAB9A (0.48) | SMN1; SMN2KMT2ANPC1RAB9APOLB | |
| SCHEMBL3475219 | 0.72 | SMN1; SMN2 (0.49) | KDM4AKDM4BKDM5CKDM5BSMN1; SMN2 | |
| SCHEMBL16991863 | 0.72 | RECQL (0.46) | KDM4AKDM4BKDM5CKDM5BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230145003-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-11 | — | — | US | disclosed |
| EP-4096667-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2022-12-07 | — | — | EP | disclosed |
| WO-2021155320-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230145003-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | KDM4A 2166/4885KDM4B 1679/4885KDM5C 2369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.