Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.50 |
| ▸ | KDM5C | P41229 | 6/20 | 0.50 |
| ▸ | KDM5A | P29375 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.50 |
| ▸ | KDM4B | O94953 | 3/20 | 0.46 |
| ▸ | KDM4A | O75164 | 3/20 | 0.46 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29129147 | 0.81 | KDM5B (0.60) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL23705892 | 0.79 | KDM4A (0.48) | KDM5BKDM5CKDM4BKDM4APOLB | |
| SCHEMBL10285171 | 0.79 | KDM5A (0.46) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL22581521 | 0.78 | KMT2A (0.49) | SMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL30607268 | 0.78 | CYP1A2 (0.47) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL8594535 | 0.78 | CYP1A2 (0.47) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL509023 | 0.78 | CYP1A2 (0.47) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL7668183 | 0.78 | CYP1A2 (0.47) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL21437557 | 0.77 | RAB9A (0.48) | POLBKDM4ESMN1; SMN2KMT2AKLKB1 | |
| SCHEMBL3475219 | 0.77 | SMN1; SMN2 (0.49) | KDM5BKDM5CKDM4BKDM4APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1762567-B1 | Pyrazole derivatives for treating HIV | PFIZER LTD (GB) | 2012-05-02 | — | — | EP | disclosed |
| US-20120029192-A1 | Pyrazole Derivatives | PFIZER INC | 2012-02-02 | — | — | US | disclosed |
| US-7435728-B2 | Pyrazole derivatives | PFIZER INC (US) | 2008-10-14 | — | — | US | disclosed |
| EP-1377556-B1 | PYRAZOLE DERIVATIVES FOR TREATING HIV | PFIZER LTD (GB) | 2007-04-04 | — | — | EP | disclosed |
| EP-1762567-A1 | Pyrazole derivatives for treating HIV | Pfizer Limited (GB) | 2007-03-14 | — | — | EP | disclosed |
| US-7109228-B2 | Pyrazole derivatives | AGOURON PHARMACEUTICALS, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| US-20060020012-A1 | Pyrazole derivatives | PFIZER INC | 2006-01-26 | — | — | US | disclosed |
| US-20030100554-A1 | Pyrazole derivatives | JONES LYN HOWARD (GB) | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060020012-A1 | Pyrazole derivatives | PDCD11, RTF1, REV1 | KDM5B 1873/4885KDM5C 1524/4885KDM5A 1292/4885 |
| US-20120029192-A1 | Pyrazole Derivatives | POLRMT, PDCD11, DPYD | KDM5B 1835/4885KDM5C 1435/4885KDM5A 1351/4885 |
| US-20030100554-A1 | Pyrazole derivatives | REV1, SARS1, CYP2F1 | KDM5B 2230/4885KDM5C 1728/4885KDM5A 1577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.