Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | HTR6 | P50406 | 1/20 | 0.66 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328225 | 0.85 | HTR2A (0.68) | HTR2AHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL5318994 | 0.84 | HTR2A (0.62) | HTR2AHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL25139456 | 0.84 | MTNR1A (0.60) | HTR2AHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL30708156 | 0.83 | MTNR1A (0.62) | HTR2AHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL21808835 | 0.83 | MTNR1A (0.62) | HTR2AHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL7867310 | 0.83 | MTNR1A (0.66) | HTR2AHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL1424902 | 0.82 | HTR2A (1.00) | HTR2AHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL26940351 | 0.82 | HTR2A (0.64) | HTR2AHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL837672 | 0.82 | HTR6 (0.74) | HTR2AHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL5791794 | 0.82 | HTR2A (0.68) | HTR2AHTR6MTNR1AMTNR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | Nimbus Saturn, Inc. (US) | 2021-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | HIPK1, PDXK, IP6K1 | HTR2A 570/4885HTR6 423/4885MTNR1A 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.