Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.51 |
| ▸ | AHCY | P23526 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPRT1 | P00492 | 6/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | TK1 | P04183 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24098412 | 0.80 | HPRT1 (0.47) | SMN1; SMN2LMNAHPRT1BLMALDH1A1 | |
| SCHEMBL24113799 | 0.77 | CDK1 (0.50) | ADORA2ASMN1; SMN2BLMKMT2AADORA1 | |
| SCHEMBL23710597 | 0.76 | LMNA (0.36) | ADORA2AAHCYSMN1; SMN2LMNAPOLB | |
| SCHEMBL7142936 | 0.74 | HPRT1 (0.67) | SMN1; SMN2LMNAHPRT1BLMALDH1A1 | |
| SCHEMBL24420506 | 0.74 | HPRT1 (0.67) | SMN1; SMN2LMNAHPRT1BLMALDH1A1 | |
| SCHEMBL23710631 | 0.74 | HPRT1 (0.67) | SMN1; SMN2LMNAHPRT1BLMALDH1A1 | |
| SCHEMBL23710566 | 0.72 | AHCY (0.68) | ADORA2AAHCYALDH1A1ADORA1ADORA2B | |
| SCHEMBL7147173 | 0.71 | AHCY (0.45) | ADORA2AAHCYSMN1; SMN2LMNAPOLB | |
| Tiviciclovir SCHEMBL15531845 | 0.69 | BLM (0.45) | SMN1; SMN2LMNAHPRT1BLMALDH1A1 | |
| SCHEMBL23240596 | 0.69 | XDH (0.31) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238595-A1 | MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT | ALNYLAM PHARMACEUTICALS, INC. (US) | 2021-08-05 | — | — | US | disclosed |