SCHEMBL2371075

SCHEMBL2371075

O=S(=O)(N[C]1CC1)c1ccc(Br)c2ccccc12

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 4/20 0.57
MEN1 O00255 3/20 0.57
KMT2A Q03164 3/20 0.57
FABP4 P15090 2/20 0.53
FABP5 Q01469 1/20 0.53
IKBKB O14920 1/20 0.42
NPSR1 Q6W5P4 2/20 0.40
MAPK10 P53779 1/20 0.40
ALDH1A1 P00352 3/20 0.39
EDNRA P25101 3/20 0.39
MCL1 Q07820 3/20 0.38
CCR8 P51685 1/20 0.38
SLC40A1 Q9NP59 1/20 0.38
GAA P10253 1/20 0.36
HTT P42858 1/20 0.36
LDHA P00338 1/20 0.36
BCL2L1 Q07817 2/20 0.36
HPGD P15428 1/20 0.35
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2372245 0.90 FABP4 (0.47) RXFP1MEN1KMT2AFABP4FABP5
SCHEMBL29540880 0.81 KMT2A (0.58) RXFP1MEN1KMT2AFABP4FABP5
SCHEMBL22234409 0.81 KMT2A (0.58) RXFP1MEN1KMT2AFABP4FABP5
SCHEMBL19297161 0.81 MEN1 (0.71) RXFP1MEN1KMT2AFABP4FABP5
SCHEMBL2372274 0.80 CYP1A2 (0.43) RXFP1MEN1KMT2AFABP4ALDH1A1
SCHEMBL2372369 0.80 GAA (0.56) FABP4FABP5NPSR1ALDH1A1GAA
SCHEMBL2372874 0.77 RXFP1 (0.54) RXFP1MEN1KMT2AFABP4FABP5
SCHEMBL2371911 0.76 FABP4 (0.60) FABP4NPSR1ALDH1A1GAAHTT
SCHEMBL19284645 0.76 FABP4 (0.56) RXFP1MEN1KMT2AFABP4FABP5
SCHEMBL2372573 0.76 HCRTR1 (0.58) MEN1KMT2AALDH1A1EDNRAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP claimed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US claimed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO claimed
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP disclosed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US disclosed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS STS, ARSA, TST RXFP1 4339/4885MEN1 4795/4885KMT2A 1543/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.