Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 2/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3105391 | 0.76 | KDM4E (0.42) | KDM4EKMT2AASPHKDM8NAPRT | |
| Hydrochloric Acid SCHEMBL9651745 | 0.75 | KDM4E (0.41) | KDM4EKMT2AASPHKDM8NAPRT | |
| SCHEMBL10465944 | 0.68 | KDM4E (0.42) | KDM4EKMT2AASPHKDM8NAPRT | |
| SCHEMBL7219568 | 0.67 | SORT1 (0.43) | KDM4EASPHKDM8 | |
| SCHEMBL31582930 | 0.65 | KDM4E (0.40) | KDM4EKMT2AASPHKDM8NAPRT | |
| SCHEMBL17188028 | 0.65 | KMO (0.37) | KDM4EKMT2AASPHKDM8NAPRT | |
| SCHEMBL9743167 | 0.63 | ALDH1A1 (0.36) | KDM4EKMT2A | |
| SCHEMBL28410539 | 0.62 | CYP1A2 (0.38) | KDM4EKMT2AASPHKDM8 | |
| SCHEMBL17611245 | 0.62 | NAPRT (0.46) | KDM4EKMT2AASPHKDM8NAPRT | |
| SCHEMBL16441038 | 0.62 | BRD4 (0.33) | KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547685-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |