Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | GLA | P06280 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23713526 | 0.90 | NPC1 (0.42) | KDM4ENPC1RAB9AMAOBGLA | |
| SCHEMBL18535678 | 0.88 | NPC1 (0.51) | KDM4ENPC1RAB9AMAOBGLA | |
| SCHEMBL23713533 | 0.87 | GLA (0.48) | KDM4ENPC1RAB9AMAOBGLA | |
| SCHEMBL23713548 | 0.87 | NPC1 (0.50) | KDM4ENPC1RAB9AMAOBGLA | |
| SCHEMBL21524284 | 0.87 | KDM4E (0.39) | THRBKDM4ENPC1RAB9AMAOB | |
| SCHEMBL23713496 | 0.85 | STS (0.37) | THRBKDM4ENPC1RAB9AMAOB | |
| SCHEMBL24046295 | 0.85 | NPC1 (0.39) | KDM4ENPC1RAB9AMAOBGLA | |
| SCHEMBL23316820 | 0.85 | GLA (0.55) | THRBKDM4ENPC1RAB9AMAOB | |
| SCHEMBL18535451 | 0.84 | THRB (0.47) | THRBKDM4ENPC1RAB9AMAOB | |
| SCHEMBL18535465 | 0.81 | CYP19A1 (0.41) | THRBKDM4EGLASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210363122-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2021-11-25 | — | — | US | disclosed |
| US-11078177-B2 | Compounds for optically active devices | MERCK PATENT GMBH (DE) | 2021-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210363122-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | PDE6C, ALDH1A2, PDE6A | THRB 4122/4885KDM4E 4039/4885NPC1 2482/4885 |
| US-11078177-B2 | Compounds for optically active devices | PDE6C, ALDH1A2, PDE6A | THRB 4122/4885KDM4E 4039/4885NPC1 2482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.