Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 7/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18535678 | 0.99 | NPC1 (0.51) | NPC1RAB9AACHEGPR55MAOB | |
| SCHEMBL18554377 | 0.92 | NPC1 (0.51) | NPC1RAB9AACHEGPR55MAOB | |
| SCHEMBL23713533 | 0.89 | GLA (0.48) | NPC1RAB9AMAOBMAOAKDM4E | |
| SCHEMBL18535674 | 0.88 | MAOB (0.49) | NPC1RAB9AACHEGPR55MAOB | |
| SCHEMBL18535477 | 0.88 | NPC1 (0.57) | NPC1RAB9AACHEGPR55MAOB | |
| SCHEMBL23316820 | 0.88 | GLA (0.55) | NPC1RAB9AMAOBMAOACYP2C19 | |
| SCHEMBL24046295 | 0.88 | NPC1 (0.39) | NPC1RAB9AACHEGPR55MAOB | |
| SCHEMBL18535535 | 0.87 | MAOB (0.50) | NPC1RAB9AACHEGPR55MAOB | |
| SCHEMBL23713532 | 0.87 | THRB (0.40) | NPC1RAB9AACHEGPR55MAOB | |
| SCHEMBL20473355 | 0.86 | ALOX5 (0.51) | NPC1RAB9AACHEGPR55MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078177-B2 | Compounds for optically active devices | MERCK PATENT GMBH (DE) | 2021-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078177-B2 | Compounds for optically active devices | PDE6C, ALDH1A2, PDE6A | NPC1 2482/4885RAB9A 930/4885ACHE 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.