SCHEMBL237136

SCHEMBL237136

COC(=O)[C@@H](N)CC(=O)N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ACE P12821 3/20 0.57
ECE1 P42892 1/20 0.53
ATM Q13315 1/20 0.51
KLK5 Q9Y337 1/20 0.51
FPR2 P25090 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8603937 0.93 ATM (0.59) ATMKLK5
SCHEMBL8603938 0.93 ATM (0.59) ATMKLK5
Hydrochloric Acid SCHEMBL10412319 0.92 ATM (0.58) ATMKLK5
SCHEMBL11406714 0.89 ATM (0.58) ATMKLK5
SCHEMBL9301967 0.89 ATM (0.58) ATMKLK5
SCHEMBL8603038 0.89 ATM (0.58) ATMKLK5
SCHEMBL6549557 0.89 ATM (0.58) ATMKLK5
Hydrochloric Acid SCHEMBL9492789 0.88 ATM (0.56) ATMKLK5
SCHEMBL6830447 0.87 ACE (0.62) ACEECE1
SCHEMBL8605262 0.87 ACE (0.62) ACEECE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8389240-B2 Method for producing α-L-aspartyl-L-phenylalanine-β-ester and method for producing α-L-aspartyl-L-phenylalanine-α-methyl ester AJINOMOTO CO., INC. (JP) 2013-03-05 US disclosed
US-8361748-B2 Method for producing α-L-aspartyl-L-phenylalanine-β-ester and method for producing α-L-aspartyl-L-phenylalanine-α-methyl ester AJINOMOTO CO., INC. (JP) 2013-01-29 US disclosed
US-20120301918-A1 METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER AJINOMOTO CO., INC. (JP) 2012-11-29 US disclosed
US-20120295304-A1 METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER AJINOMOTO CO., INC. (JP) 2012-11-22 US disclosed
EP-2180060-B1 Method for produding alpha-L-aspartyl-L-phenylalanine-beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester AJINOMOTO KK (JP) 2012-08-29 EP disclosed
EP-2180061-B1 Method for producing alpha-L-aspartyl-L-phenylalanine-beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester AJINOMOTO KK (JP) 2012-08-29 EP disclosed
US-8247193-B2 Method for producing α-L-aspartyl-L-phenylalanine-β-ester and method for producing α-L-aspartyl-L-phenylalanine-α-methyl ester AJINOMOTO CO., INC. (JP) 2012-08-21 US disclosed
EP-2180059-B1 Method for producing alpha-L-aspartyl-L-phenylalanine-beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester AJINOMOTO KK (JP) 2012-06-27 EP disclosed
EP-2157188-B1 Method for producing alpha-L-Aspartyl-L-phenylalanine-Beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester AJINOMOTO KK (JP) 2012-05-02 EP disclosed
EP-2166109-B1 Method for producing alpha-L-aspartyl-L-phenylalanine-beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester AJINOMOTO KK (JP) 2012-02-22 EP disclosed
US-7361458-B2 Method for producing α-L-aspartyl-L-phenylalanine-β-ester and method for producing α-L-aspartyl-L-phenylalanine-α-methyl ester AJINOMOTO CO., INC. (JP) 2008-04-22 US disclosed
EP-1587941-A4 METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER AJINOMOTO KK (JP) 2006-06-21 EP disclosed
EP-1587941-A1 METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER Ajinomoto Co., Inc. (JP) 2005-10-26 EP disclosed
US-20050124035-A1 Method for producing alpha-L-aspartyl-L-phenylalanine-beta-ester and methd for producing alpha-L-aspartyl-l-phenylalanine-alpha-methyl esther AJINOMOTO CO., INC. (JP) 2005-06-09 US disclosed
WO-2004065610-A1 METHOD FOR PRODUCING α- L-ASPARTYL-L-PHENYLALANINE-β-ESTER AND METHOD FOR PRODUCING α-L-ASPARTYL-L-PHENYLALANINE-α-METHYL ESTER AJINOMOTO CO., INC. (JP) 2004-08-05 WO disclosed
EP-0297560-B1 Imides; a process for their production and a process for the production of dipeptides using them AJINOMOTO KK (JP) 1998-03-04 EP disclosed
EP-0327030-B1 Method for producing alpha-aspartylphenylalanine derivatives AJINOMOTO KK (JP) 1995-01-25 EP disclosed
US-4904802-A Imides AJINOMOTO CO., INC. (JP) 1990-02-27 US disclosed
EP-0297560-A2 Imides; a process for their production and a process for the production of dipeptides using them Ajinomoto Co., Inc. (JP) 1989-01-04 EP disclosed
US-4673744-A IN ALCOHOL SOLVENT AJINOMOTO CO., INC. (JP) 1987-06-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050124035-A1 Method for producing alpha-L-aspartyl-L-phenylalanine-beta-ester and methd for producing alpha-L-aspartyl-l-phenylalanine-alpha-methyl esther DNPEP, ASPH, PEPD ACE 74/4885ECE1 125/4885ATM 1571/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.