Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 6/20 | 0.32 |
| ▸ | DRD3 | P35462 | 6/20 | 0.32 |
| ▸ | DRD1 | P21728 | 4/20 | 0.32 |
| ▸ | DRD4 | P21917 | 4/20 | 0.32 |
| ▸ | DRD5 | P21918 | 4/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22124736 | 0.74 | PDE4A (0.40) | PDE4APDE4CPDE4DCA1CA2 | |
| SCHEMBL3946288 | 0.71 | SMN1; SMN2 (0.36) | PDE4APDE4CPDE4DDRD2DRD3 | |
| SCHEMBL16922264 | 0.70 | PDE4A (0.47) | PDE4APDE4CPDE4DCA1CA2 | |
| SCHEMBL23705953 | 0.68 | PDE4A (0.34) | PDE4APDE4CPDE4D | |
| SCHEMBL6299075 | 0.67 | L3MBTL1 (0.33) | PDE4APDE4CPDE4D | |
| SCHEMBL6293194 | 0.67 | L3MBTL1 (0.33) | PDE4APDE4CPDE4D | |
| SCHEMBL6299079 | 0.67 | TOP2A (0.36) | PDE4APDE4CPDE4DHTR1D | |
| SCHEMBL31049812 | 0.67 | PDE4A (0.39) | PDE4APDE4CPDE4DDRD1CA1 | |
| SCHEMBL13514274 | 0.67 | LMNA (0.33) | PDE4APDE4CPDE4DDRD2DRD3 | |
| SCHEMBL17591275 | 0.67 | NUDT1 (0.30) | NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155320-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |