Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.34 |
| ▸ | ESR1 | P03372 | 4/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19469638 | 0.88 | ALDH1A1 (0.41) | OPRM1ADRA2AESR2ESR1SIGMAR1 | |
| SCHEMBL30058891 | 0.81 | KDM1A (0.46) | KDM1A | |
| SCHEMBL23704864 | 0.81 | KDM1A (0.46) | KDM1A | |
| SCHEMBL19469456 | 0.78 | CYP3A4 (0.47) | OPRM1ADRA2ASIGMAR1ALDH1A1CYP3A4 | |
| SCHEMBL12247403 | 0.78 | SIGMAR1 (0.43) | KDM1ASIGMAR1ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL23705405 | 0.76 | KDM1A (0.51) | KDM1AALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL9770689 | 0.75 | CYP3A4 (0.41) | ADRA2AKDM1ASIGMAR1ALDH1A1CYP3A4 | |
| SCHEMBL30695369 | 0.75 | CYP3A4 (0.41) | ADRA2AKDM1ASIGMAR1ALDH1A1CYP3A4 | |
| SCHEMBL23714665 | 0.75 | OPRM1 (0.30) | OPRM1 | |
| SCHEMBL23714634 | 0.73 | RARB (0.36) | KDM1AALDH1A1CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155316-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |