Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21881533 | 0.86 | LMNA (0.71) | LMNARECQLHPGDHDAC3HDAC1 | |
| SCHEMBL23619652 | 0.83 | F11 (0.57) | LMNA | |
| SCHEMBL21881532 | 0.81 | LMNA (0.63) | LMNARECQLPOLBALDH1A1 | |
| SCHEMBL15443325 | 0.80 | RECQL (0.68) | LMNARECQLHPGDPOLBSMN1; SMN2 | |
| SCHEMBL9912035 | 0.79 | LMNA (0.60) | LMNARECQLPOLBSMN1; SMN2MEN1 | |
| SCHEMBL6391981 | 0.79 | CNR1 (0.53) | LMNAALDH1A1 | |
| SCHEMBL21444578 | 0.78 | RECQL (0.91) | LMNARECQLHPGDPOLBSMN1; SMN2 | |
| SCHEMBL517633 | 0.78 | RECQL (0.91) | LMNARECQLHPGDPOLBSMN1; SMN2 | |
| SCHEMBL9927461 | 0.78 | RECQL (0.91) | LMNARECQLHPGDPOLBSMN1; SMN2 | |
| SCHEMBL9282167 | 0.78 | GAA (0.51) | LMNAHPGDMEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |