Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14809955 | 0.63 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2GRM5 | |
| SCHEMBL13188319 | 0.62 | KDM4E (0.66) | KDM4EALDH1A1SMN1; SMN2NPC1OPRK1 | |
| SCHEMBL947645 | 0.61 | LCLAT1 (0.48) | KDM4EGRM5MEN1KMT2A | |
| SCHEMBL23720730 | 0.61 | MAP3K5 (0.36) | — | |
| SCHEMBL5700127 | 0.61 | ALDH1A1 (0.57) | KDM4EALDH1A1SMN1; SMN2NPC1OPRK1 | |
| SCHEMBL5700497 | 0.61 | ALDH1A1 (0.68) | KDM4EALDH1A1SMN1; SMN2NPC1OPRK1 | |
| SCHEMBL29478760 | 0.61 | ALDH1A1 (0.68) | KDM4EALDH1A1SMN1; SMN2NPC1OPRK1 | |
| SCHEMBL29679606 | 0.60 | ALDH1A1 (0.61) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1505656 | 0.60 | ALDH1A1 (0.61) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15104865 | 0.57 | L3MBTL1 (0.56) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858824-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |