Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MAP2 | P11137 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189335 | 0.88 | LMNA (0.51) | LMNACSF1RCYP1A2GAAHPGD | |
| SCHEMBL6990287 | 0.86 | KDM4E (0.46) | LMNACSF1RHPGDKDM4EALDH1A1 | |
| SCHEMBL613136 | 0.83 | LMNA (0.51) | LMNACSF1RCYP1A2GAAHPGD | |
| SCHEMBL8889498 | 0.82 | KEAP1 (0.50) | LMNAGAAHPGDKDM4EALDH1A1 | |
| SCHEMBL8183478 | 0.81 | SIRT1 (0.54) | CSF1RHPGDKDM4ESIRT1GRIN2D | |
| SCHEMBL11375916 | 0.80 | KDM4E (0.61) | CSF1RCYP1A2KDM4EGRIN2DGRIN3B | |
| SCHEMBL25430492 | 0.79 | SIRT1 (0.52) | LMNACSF1RCYP1A2GAAHPGD | |
| SCHEMBL31139832 | 0.79 | SIRT1 (0.52) | LMNACSF1RCYP1A2GAAHPGD | |
| SCHEMBL7000905 | 0.78 | CSF1R (0.48) | LMNACSF1RCYP1A2GAAHPGD | |
| SCHEMBL4895906 | 0.78 | KDM4E (0.72) | LMNACYP1A2GAAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| US-6114349-A | Substituted quinoline derivatives with antiviral action | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-09-05 | — | — | US | disclosed |