Biotin

Biotin

SCHEMBL23722253

NC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21

nearest known ligand 0.90

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 6/20 0.90
MEN1 O00255 1/20 0.90
ABL1 P00519 1/20 0.90
LMNA P02545 1/20 0.90
PKM P14618 1/20 0.90
IDE P14735 1/20 0.90
MAPK1 P28482 1/20 0.90
KMT2A Q03164 1/20 0.90
RIN1 Q13671 1/20 0.90
L3MBTL1 Q9Y468 1/20 0.90
HLCS P50747 6/20 0.63
CA12 O43570 7/20 0.54
CA1 P00915 7/20 0.54
CA2 P00918 7/20 0.54
CA9 Q16790 7/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biotin SCHEMBL4957081 0.99 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL28516341 0.96 TDP1 (0.92) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL9387622 0.96 TDP1 (0.92) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL27481189 0.95 TDP1 (0.81) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL6137130 0.95 TDP1 (0.81) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL1199492 0.95 TDP1 (0.94) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL636444 0.95 TDP1 (0.94) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL22943835 0.95 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
SCHEMBL14417103 0.95 TDP1 (0.79) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL20547409 0.95 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285464-A1 NOVEL CELLULAR RECEPTORS AND USES THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2023-09-14 US disclosed
US-11672828-B2 Cellular receptors and uses thereof TRUSTEES OF BOSTON UNIVERSITY (US) 2023-06-13 US disclosed
WO-2021163018-A1 NOVEL CELLULAR RECEPTORS AND USES THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2021-08-19 WO disclosed
US-20210244764-A1 NOVEL CELLULAR RECEPTORS AND USES THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2021-08-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210244764-A1 NOVEL CELLULAR RECEPTORS AND USES THEREOF SRPRA, CACYBP, SRPRB TDP1 3400/4885MEN1 4246/4885ABL1 4564/4885
US-11672828-B2 Cellular receptors and uses thereof SRPRA, NPBWR1, BCAP31 TDP1 3462/4885MEN1 3868/4885ABL1 4348/4885
US-20230285464-A1 NOVEL CELLULAR RECEPTORS AND USES THEREOF SRPRA, CACYBP, SRPRB TDP1 3400/4885MEN1 4246/4885ABL1 4564/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.