Sugi Predict

Sugi Predict / Compounds / Biotin

Biotin

Biotin

SCHEMBL636444

NO.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.94
▸ MEN1 O00255 1/20 0.94
▸ ABL1 P00519 1/20 0.94
▸ LMNA P02545 1/20 0.94
▸ PKM P14618 1/20 0.94
▸ IDE P14735 1/20 0.94
▸ MAPK1 P28482 1/20 0.94
▸ KMT2A Q03164 1/20 0.94
▸ RIN1 Q13671 1/20 0.94
▸ L3MBTL1 Q9Y468 1/20 0.94
▸ HLCS P50747 6/20 0.66
▸ CA12 O43570 7/20 0.56
▸ CA1 P00915 7/20 0.56
▸ CA2 P00918 7/20 0.56
▸ CA9 Q16790 7/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biotin SCHEMBL1199492 0.97 TDP1 (0.94) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL410686 0.97 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL21981206 0.97 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL826595 0.97 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL59420 0.97 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL23055065 0.97 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL20547409 0.97 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL22943835 0.97 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL36572 0.97 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL9841217 0.97 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024059788-A2 METHOD, KIT AND SYSTEM FOR END LABELING OF NUCLEIC ACIDS Chen cheng yao 2024-03-21 — — WO claimed
CN-115976174-A Single base resolution positioning analysis method and kit for 5-aldehyde cytosine in DNA 武汉大学 2023-04-18 — — CN claimed
CN-118184728-A Method for selectively modifying polypeptide or protein lysine 国科大杭州高等研究院 2024-06-14 — — CN disclosed
US-20240150837-A1 METHODS AND SYSTEMS FOR METHYLATION PROFILING OF PREGNANCY-RELATED STATES MIRVIE, INC. 2024-05-09 — — US disclosed
US-11958880-B2 Means and methods for site-specific functionalization of polypeptides LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2024-04-16 — — US disclosed
EP-4341438-A2 METHODS AND SYSTEMS FOR METHYLATION PROFILING OF PREGNANCY-RELATED STATES Mirvie, Inc. (US) 2024-03-27 — — EP disclosed
WO-2024059788-A2 METHOD, KIT AND SYSTEM FOR END LABELING OF NUCLEIC ACIDS Chen cheng yao 2024-03-21 — — WO disclosed
WO-2023230618-A1 METHOD, KITS AND SYSTEM FOR DUAL LABELING OF NUCLEIC ACIDS Chen cheng yao 2023-11-30 — — WO disclosed
CN-115976174-A Single base resolution positioning analysis method and kit for 5-aldehyde cytosine in DNA 武汉大学 2023-04-18 — — CN disclosed
CN-115976174-A Single base resolution positioning analysis method and kit for 5-aldehyde cytosine in DNA 武汉大学 2023-04-18 — — CN disclosed
EP-3912642-B1 MODIFIED ANTIBODY, ANTIBODY-CONJUGATE AND PROCESS FOR THE PREPARATION THEREOF SYNAFFIX BV (NL) 2023-04-12 — — EP disclosed
WO-2007057746-A2 FOCUSED MICROARRAY AND METHODS OF DIAGNOSING CHEMOTHERAPEUTIC DRUG RESISTANCE IN A CANCER CELL AURELIUM BIOPHARMA INC. (US) 2007-05-24 — — WO disclosed
US-20070077583-A1 Alpha enolase-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance AURELIUM BIOPHARMA, INC. (CA) 2007-04-05 — — US disclosed
US-20060275810-A1 Focused microarray and methods of diagnosing chemotherapeutic drug resistance in a cancer cell AURELIUM BIOPHARMA INC. (CA) 2006-12-07 — — US disclosed
WO-2006110182-A2 ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS THE SCRIPPS RESEARCH INSTITUTE (US) 2006-10-19 — — WO disclosed
US-6967251-B2 Reagents for labeling biomolecules having aldehyde or ketone moieties MOLECULAR PROBES, INC. (US) 2005-11-22 — — US disclosed
US-20050250152-A1 Reagents for labeling biomolecules having aldehyde or ketone moieties MOLECULAR PROBES, INC. 2005-11-10 — — US disclosed
EP-1322625-A2 REAGENTS FOR LABELING BIOMOLECULES HAVING ALDEHYDE OR KETONE MOIETIES Molecular Probes Inc. (US) 2003-07-02 — — EP disclosed
US-20020137068-A1 Reagents for labeling biomolecules having aldehyde or ketone Moieties MOLECULAR PROBES, INC. 2002-09-26 — — US disclosed
WO-2002028841-A2 REAGENTS FOR LABELING BIOMOLECULES HAVING ALDEHYDE OR KETONE MOIETIES MOLECULAR PROBES, INC. (US) 2002-04-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020137068-A1 Reagents for labeling biomolecules having aldehyde or ketone Moieties DERA, HLCS, CD44 TDP1 3240/4885MEN1 4758/4885ABL1 4049/4885
US-11958880-B2 Means and methods for site-specific functionalization of polypeptides PTMS, DNPEP, LNPEP TDP1 2993/4885MEN1 2225/4885ABL1 578/4885
US-20050250152-A1 Reagents for labeling biomolecules having aldehyde or ketone moieties QPCTL, FGB, QPCT TDP1 3097/4885MEN1 4868/4885ABL1 1820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.