Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.33 |
| ▸ | DUT | P33316 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22204295 | 1.00 | ALOX5 (0.35) | ALOX5PTGER2PTGDRDUTPTGER3 | |
| SCHEMBL22204145 | 1.00 | ALOX5 (0.35) | ALOX5PTGER2PTGDRDUTPTGER3 | |
| SCHEMBL16098829 | 0.79 | DUT (0.35) | PTGER2PTGDRDUTPTGER3TOP2A | |
| SCHEMBL16098826 | 0.79 | DUT (0.35) | PTGER2PTGDRDUTPTGER3TOP2A | |
| SCHEMBL850848 | 0.75 | PTGER2 (0.36) | PTGER2PTGDRDUTPTGER3TOP2A | |
| SCHEMBL848123 | 0.75 | PTGER2 (0.36) | PTGER2PTGDRDUTPTGER3TOP2A | |
| SCHEMBL21314771 | 0.75 | HDAC1 (0.36) | PTGER2PTGDRDUTPTGER3 | |
| SCHEMBL21314774 | 0.75 | HDAC1 (0.36) | PTGER2PTGDRDUTPTGER3 | |
| SCHEMBL30832924 | 0.75 | HDAC1 (0.36) | PTGER2PTGDRDUTPTGER3 | |
| SCHEMBL13109271 | 0.74 | PTGER2 (0.56) | PTGER2PTGDRDUTPTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246130-A1 | DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | ASTRAZENECA AB (SE) | 2021-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210246130-A1 | DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | PIK3CD, PIK3CG, PRKCG | ALOX5 3158/4885PTGER2 1207/4885PTGDR 948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.