Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 15/20 | 0.50 |
| ▸ | TACR2 | P21452 | 11/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372651 | 0.92 | TRPV4 (0.46) | TACR3TACR2OPRM1KCNH2KDM4E | |
| SCHEMBL2373237 | 0.90 | TRPV4 (0.49) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL6951612 | 0.89 | TACR3 (0.47) | TACR3TACR2OPRM1KCNH2POLB | |
| Hydrochloric Acid SCHEMBL7077944 | 0.89 | TACR3 (0.47) | TACR3TACR2OPRM1KCNH2POLB | |
| SCHEMBL7080701 | 0.85 | LMNA (0.50) | TACR3TACR2OPRM1KCNH2KDM4E | |
| SCHEMBL7076527 | 0.85 | TACR3 (0.54) | TACR3TACR2OPRM1KCNH2ALDH1A1 | |
| SCHEMBL7165599 | 0.84 | TACR3 (0.43) | TACR3TACR2OPRM1KCNH2KDM4E | |
| SCHEMBL6582324 | 0.83 | DHODH (0.42) | TACR3TACR2OPRM1KCNH2ALDH1A1 | |
| SCHEMBL2372735 | 0.82 | TRPV4 (0.43) | TACR3TACR2KCNH2TRPV4 | |
| SCHEMBL6586109 | 0.81 | TRPV4 (0.43) | TACR3TACR2OPRM1KCNH2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |