Sugi Predict

Sugi Predict / Compounds / SCHEMBL23725473

SCHEMBL23725473

SCHEMBL23725473

Cn1cc(C=O)c2cnc(Cl)cc21

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.48
▸ IMPDH2 P12268 1/20 0.47
▸ KDM4E B2RXH2 2/20 0.46
▸ KDR P35968 4/20 0.34
▸ BRD4 O60885 2/20 0.34
▸ MAP3K5 Q99683 3/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ MAPT P10636 1/20 0.33
▸ MPI P34949 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ CDC7 O00311 1/20 0.31
▸ POLB P06746 2/20 0.30
▸ NPC1 O15118 1/20 0.30
▸ USP2 O75604 1/20 0.30
▸ RAB9A P51151 1/20 0.30
▸ RXFP1 Q9HBX9 1/20 0.30
▸ GPR55 Q9Y2T6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15742007 0.80 MEN1 (0.33) ALDH1A1IMPDH2KDM4EBRD4MEN1
SCHEMBL30995726 0.73 ALDH1A1 (0.62) ALDH1A1IMPDH2KDM4EKDRMEN1
SCHEMBL1093940 0.73 ALDH1A1 (0.62) ALDH1A1IMPDH2KDM4EKDRMEN1
SCHEMBL23725218 0.71 ALDH1A1 (0.40) ALDH1A1IMPDH2KDM4EMEN1KMT2A
SCHEMBL25175493 0.71 HPGD (0.42) ALDH1A1IMPDH2KDM4EKDRMEN1
SCHEMBL1093666 0.70 ALDH1A1 (0.66) ALDH1A1IMPDH2KDM4EKDRMEN1
SCHEMBL10426504 0.70 ALDH1A1 (0.59) ALDH1A1IMPDH2KDM4EKDRMEN1
SCHEMBL20952219 0.70 NR4A2 (0.52) ALDH1A1KDM4EBRD4MAP3K5MEN1
SCHEMBL30617319 0.70 NR4A2 (0.52) ALDH1A1KDM4EBRD4MAP3K5MEN1
SCHEMBL12344901 0.69 ALDH1A1 (0.56) ALDH1A1IMPDH2KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230143612-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (US) 2023-05-11 — — US disclosed
US-20230143612-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (US) 2023-05-11 — — US disclosed
US-20230143612-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (US) 2023-05-11 — — US disclosed
EP-4100381-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME Arbutus Biopharma Corporation (CA) 2022-12-14 — — EP disclosed
CN-115413275-A Substituted 1,1 , -biphenyl compounds and methods of use thereof 爱彼特生物制药公司 2022-11-29 — — CN disclosed
WO-2021158481-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME ARBUTUS BIOPHARMA, INC. (US) 2021-08-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143612-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME HAVCR2, HMBS, VHL ALDH1A1 172/4885IMPDH2 1072/4885KDM4E 224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.