Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16755660 | 0.81 | ALDH1A1 (0.40) | ALDH1A1IMPDH2KDM4ELRRK2MEN1 | |
| SCHEMBL22518612 | 0.78 | LRRK2 (0.52) | LRRK2KMT2ASMN1; SMN2CDK1PDE2A | |
| SCHEMBL30475607 | 0.78 | LRRK2 (0.52) | LRRK2KMT2ASMN1; SMN2CDK1PDE2A | |
| SCHEMBL25522940 | 0.76 | LRRK2 (0.38) | LRRK2SMN1; SMN2CDK1PDE2AYTHDC1 | |
| SCHEMBL25169082 | 0.75 | ALDH1A1 (0.45) | ALDH1A1IMPDH2KDM4EMEN1MAPT | |
| SCHEMBL30955629 | 0.75 | LRRK2 (0.38) | LRRK2MEN1KMT2ASMN1; SMN2CDK1 | |
| SCHEMBL30475605 | 0.75 | LRRK2 (0.38) | LRRK2SMN1; SMN2CDK1PDE2AYTHDC1 | |
| SCHEMBL22518608 | 0.75 | LRRK2 (0.38) | LRRK2SMN1; SMN2CDK1PDE2AYTHDC1 | |
| SCHEMBL23725473 | 0.71 | ALDH1A1 (0.48) | ALDH1A1IMPDH2KDM4EMEN1MAPT | |
| SCHEMBL22518631 | 0.71 | LRRK2 (0.59) | LRRK2SMN1; SMN2CDK1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| CN-115413275-A | Substituted 1,1 , -biphenyl compounds and methods of use thereof | 爱彼特生物制药公司 | 2022-11-29 | — | — | CN | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | HAVCR2, HMBS, VHL | ALDH1A1 172/4885IMPDH2 1072/4885KDM4E 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.