Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 20/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 17/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23724879 | 0.83 | CD274 (0.43) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL23724875 | 0.83 | CD274 (0.43) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL29983679 | 0.83 | CD274 (0.43) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL27080770 | 0.83 | PRF1 (0.34) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL23725965 | 0.77 | CD274 (0.36) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL27080414 | 0.77 | CD274 (0.36) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL20243509 | 0.76 | PRF1 (0.42) | — | |
| SCHEMBL25688688 | 0.74 | PDCD1 (0.37) | CD274PDCD1 | |
| SCHEMBL22226945 | 0.71 | MAPK1 (0.44) | — | |
| SCHEMBL30592769 | 0.69 | GABRA1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |