Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410432 | 0.85 | HCAR1 (0.36) | HCAR1ENPP3ENPP1CA1CA2 | |
| SCHEMBL1041762 | 0.85 | SMN1; SMN2 (0.40) | HCAR1ENPP3ENPP1CA1CA2 | |
| SCHEMBL29362666 | 0.85 | HCAR1 (0.36) | HCAR1ENPP3ENPP1CA1CA2 | |
| SCHEMBL22990013 | 0.85 | HCAR1 (0.36) | HCAR1ENPP3ENPP1CA1CA2 | |
| SCHEMBL31003817 | 0.83 | HCAR1 (0.36) | HCAR1ENPP3ENPP1CA1CA2 | |
| SCHEMBL22660409 | 0.83 | NOTUM (0.38) | HCAR1ENPP3ENPP1CA1CA2 | |
| SCHEMBL15748386 | 0.83 | CA2 (0.36) | HCAR1ENPP3ENPP1CA1CA2 | |
| SCHEMBL22660160 | 0.83 | HCAR1 (0.36) | HCAR1ENPP3ENPP1CA1CA2 | |
| SCHEMBL696825 | 0.83 | ALDH1A1 (0.48) | HCAR1ENPP3ENPP1CA1CA2 | |
| SCHEMBL3278921 | 0.83 | NOTUM (0.42) | HCAR1ENPP3ENPP1PDK2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112479988-B | Substituted biphenyl compound, preparation method, application and pharmaceutical composition thereof | 药康众拓(江苏)医药科技有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117412959-A | Substituted 1-aryl-1 '-heteroaryl compounds, substituted 1,1' -biaryl compounds, and methods of use thereof | 爱彼特生物制药公司 | 2024-01-16 | — | — | CN | disclosed |
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| CN-115413275-A | Substituted 1,1 , -biphenyl compounds and methods of use thereof | 爱彼特生物制药公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-114388703-A | Organic electroluminescent device and polycyclic compound for organic electroluminescent device | 三星显示有限公司 | 2022-04-22 | — | — | CN | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
| CN-112479988-A | Substituted biphenyl compound, preparation method, application and pharmaceutical composition thereof | 中国药科大学 | 2021-03-12 | — | — | CN | disclosed |