SCHEMBL2372669

SCHEMBL2372669

[CH2]NS(=O)(=O)c1cccc2c(NC(C)=O)cccc12

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 1/20 0.57
KMT2A Q03164 2/20 0.51
MEN1 O00255 1/20 0.47
RXFP1 Q9HBX9 1/20 0.46
CASP6 P55212 1/20 0.46
SLC40A1 Q9NP59 1/20 0.43
PKM P14618 2/20 0.43
ALDH1A1 P00352 2/20 0.42
HPGD P15428 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MAPT P10636 1/20 0.42
LMNA P02545 1/20 0.41
TSHR P16473 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
USP30 Q70CQ3 1/20 0.41
MAOA P21397 1/20 0.41
CCR8 P51685 1/20 0.41
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2371826 0.91 KMT2A (0.58) EDNRAKMT2ARXFP1PKMALDH1A1
SCHEMBL6073751 0.86 EDNRA (0.58) EDNRAKMT2AMEN1RXFP1CASP6
SCHEMBL8054308 0.85 EDNRA (0.57) EDNRAKMT2AMEN1RXFP1CASP6
SCHEMBL20565327 0.84 NSD2 (0.57) EDNRAKMT2AUSP30
SCHEMBL15461567 0.83 EDNRA (0.54) EDNRAKMT2AMEN1RXFP1CASP6
SCHEMBL6073527 0.83 CASP6 (0.60) EDNRAKMT2AMEN1RXFP1CASP6
SCHEMBL23092875 0.82 EDNRA (0.55) EDNRAKMT2AMEN1RXFP1CASP6
SCHEMBL29900505 0.82 EDNRA (0.55) EDNRAKMT2AMEN1RXFP1CASP6
SCHEMBL2371364 0.82 EDNRA (0.46) EDNRASLC40A1
SCHEMBL3529089 0.81 EDNRA (0.53) EDNRAKMT2AMEN1RXFP1CASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP claimed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US claimed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO claimed
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP disclosed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US disclosed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS STS, ARSA, TST EDNRA 4428/4885KMT2A 1543/4885MEN1 4795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.