Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 14/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.53 |
| ▸ | MMP2 | P08253 | 3/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.34 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30012305 | 0.80 | MMP2 (0.32) | ADAMTS5ADAM17MMP2MMP14ACE | |
| SCHEMBL29835171 | 0.74 | ADAMTS5 (0.55) | ADAMTS5ADAM17MMP2MMP14ADAMTS4 | |
| SCHEMBL23745343 | 0.74 | ADAMTS5 (0.55) | ADAMTS5ADAM17MMP2MMP14ADAMTS4 | |
| SCHEMBL23745290 | 0.72 | ADAMTS5 (0.45) | ADAMTS5ADAM17ADAM10ADAMTS4MMP12 | |
| SCHEMBL17871566 | 0.69 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2MMP14ADAM10 | |
| SCHEMBL17884949 | 0.68 | ADAMTS5 (0.49) | ADAMTS5ADAM17MMP2MMP14ADAMTS4 | |
| SCHEMBL22063167 | 0.67 | ADAMTS5 (0.74) | ADAMTS5ADAM17MMP2MMP14ADAM10 | |
| SCHEMBL23745474 | 0.67 | HSP90AA1 (0.30) | — | |
| SCHEMBL20708354 | 0.66 | ADAMTS5 (0.77) | ADAMTS5ADAM17MMP2MMP14ADAM10 | |
| SCHEMBL30013124 | 0.66 | ADAMTS5 (0.54) | ADAMTS5ADAM17MMP2MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100005-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158626-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Eternity Bioscience Inc. (US) | 2021-08-12 | — | — | WO | disclosed |