Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 4/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30013015 | 0.80 | ADAMTS5 (0.64) | ADAMTS5ADAM17DPP7DPP4FAP | |
| SCHEMBL23745207 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAM17DPP7MMP14 | |
| SCHEMBL31121196 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAM17DPP7MMP14 | |
| SCHEMBL31121172 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAM17DPP7MMP14 | |
| SCHEMBL23728086 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAM17DPP7MMP14 | |
| SCHEMBL23745210 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAM17DPP7MMP14 | |
| SCHEMBL23745208 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAM17DPP7MMP14 | |
| SCHEMBL23745205 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAM17DPP7MMP14 | |
| SCHEMBL31121170 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAM17DPP7MMP14 | |
| SCHEMBL23745286 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAM17DPP7MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100005-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2022-12-14 | — | — | EP | disclosed |