Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.34 |
| ▸ | AR | P10275 | 6/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29835164 | 1.00 | PDE3B (0.36) | PDE3BPDE3ANOTUMARMKNK2 | |
| SCHEMBL23727325 | 1.00 | PDE3B (0.36) | PDE3BPDE3ANOTUMARMKNK2 | |
| SCHEMBL23745465 | 0.81 | MKNK2 (0.38) | MKNK2MKNK1HTR2CTSHRSMN1; SMN2 | |
| SCHEMBL23727834 | 0.81 | MKNK2 (0.38) | MKNK2MKNK1HTR2CTSHRSMN1; SMN2 | |
| SCHEMBL24728783 | 0.71 | P2RX7 (0.36) | PDE3BPDE3ANOTUMARHTR2C | |
| SCHEMBL19117220 | 0.69 | MKNK2 (0.36) | ARMKNK2MKNK1DAO | |
| SCHEMBL14992148 | 0.68 | PPOX (0.46) | MKNK2MKNK1HTR2CTSHRHTR2A | |
| SCHEMBL14991575 | 0.68 | MKNK2 (0.46) | MKNK2MKNK1HTR2CHTR2AHTR2B | |
| SCHEMBL23728136 | 0.67 | PNMT (0.36) | PDE3BPDE3ANOTUMHTR2CTSHR | |
| SCHEMBL22519758 | 0.66 | HTR2C (0.38) | PDE3BPDE3ANOTUMARDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100005-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158626-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Eternity Bioscience Inc. (US) | 2021-08-12 | — | — | WO | disclosed |