Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | TAS2R38 | P59533 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ABAT | P80404 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730314 | 0.86 | ALDH1A1 (0.80) | EPHX1ALDH1A1TAS2R38HSD17B10CYP3A4 | |
| SCHEMBL3083065 | 0.83 | EPHX1 (0.67) | EPHX1ALDH1A1TAS2R38HSD17B10CYP3A4 | |
| N-(Phenylcarbamothioyl)Acetamide SCHEMBL5458065 | 0.83 | EPHX1 (1.00) | EPHX1ALDH1A1TAS2R38HSD17B10CYP3A4 | |
| SCHEMBL2254530 | 0.83 | ALDH1A1 (0.63) | EPHX1ALDH1A1HSD17B10LMNANPC1 | |
| N-(Phenylcarbamothioyl)Benzamide SCHEMBL2341910 | 0.82 | EPHX1 (1.00) | EPHX1ALDH1A1GAANPC1RAB9A | |
| SCHEMBL132620 | 0.81 | ALDH1A1 (1.00) | ALDH1A1TAS2R38HSD17B10CYP3A4GAA | |
| SCHEMBL6872123 | 0.80 | GAA (0.72) | EPHX1ALDH1A1TAS2R38HSD17B10CYP3A4 | |
| SCHEMBL4174363 | 0.80 | CA12 (0.55) | EPHX1ALDH1A1CYP3A4LMNANPC1 | |
| SCHEMBL5695334 | 0.80 | RAB9A (0.71) | ALDH1A1LMNANPC1RAB9AKMT2A | |
| SCHEMBL14860311 | 0.79 | EPHX1 (0.78) | EPHX1ALDH1A1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111875558-B | Thiazolidine derivative and application thereof in depression resistance | 深圳市第二人民医院(深圳市转化医学研究院) | 2022-07-01 | — | — | CN | claimed |
| CN-111909111-B | 5-alkyl thiazolamine derivative and application thereof in depression resistance | 深圳市第二人民医院(深圳市转化医学研究院) | 2022-07-01 | — | — | CN | claimed |
| CN-109456279-A | Thiazoleamino benzamide acetic ester derivative and application thereof | 南华大学 | 2019-03-12 | — | — | CN | claimed |
| CN-109320473-A | Thiazoleamino benzamide acetogenin and application thereof | 南华大学 | 2019-02-12 | — | — | CN | claimed |
| CN-109232467-A | Thiazoleamino benzoic acid derivative and application thereof | 南华大学 | 2019-01-18 | — | — | CN | claimed |
| US-12617785-B2 | Pyrrolo[2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss | THE ROCKEFELLER UNIVERSITY (US) | 2026-05-05 | — | — | US | disclosed |
| EP-4100008-B1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | UNIV ROCKEFELLER (US) | 2025-04-02 | — | — | EP | disclosed |
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2023-05-04 | — | — | US | disclosed |
| EP-4100008-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | The Rockefeller University (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158936-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2021-08-12 | — | — | WO | disclosed |
| CN-109456279-A | Thiazoleamino benzamide acetic ester derivative and application thereof | 南华大学 | 2019-03-12 | — | — | CN | disclosed |
| CN-109320473-A | Thiazoleamino benzamide acetogenin and application thereof | 南华大学 | 2019-02-12 | — | — | CN | disclosed |
| CN-109232467-A | Thiazoleamino benzoic acid derivative and application thereof | 南华大学 | 2019-01-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12617785-B2 | Pyrrolo[2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss | YAP1, LATS2, LATS1 | EPHX1 4502/4885ALDH1A1 2546/4885TAS2R38 1987/4885 |
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | LATS2, LATS1, YAP1 | EPHX1 4321/4885ALDH1A1 3775/4885TAS2R38 1346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.