Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17729288 | 0.83 | PTGS1 (0.50) | PTGS1PTGS2KDM4ERAB9ANPC1 | |
| SCHEMBL118449 | 0.79 | PTGS1 (1.00) | PTGS1PTGS2KDM4ERAB9ANPC1 | |
| SCHEMBL2334973 | 0.78 | PTGS1 (0.96) | PTGS1PTGS2KDM4ERAB9ANPC1 | |
| Water SCHEMBL21708935 | 0.78 | PTGS1 (0.96) | PTGS1PTGS2KDM4ERAB9ANPC1 | |
| Bromide SCHEMBL570786 | 0.78 | PTGS1 (0.96) | PTGS1PTGS2KDM4ERAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL8878519 | 0.78 | PTGS1 (0.96) | PTGS1PTGS2KDM4ERAB9ANPC1 | |
| SCHEMBL22835342 | 0.74 | PTGS1 (0.45) | PTGS1PTGS2KDM4EALOX15TSHR | |
| SCHEMBL1815553 | 0.72 | KDM4E (0.47) | PTGS1PTGS2KDM4EALOX15TSHR | |
| SCHEMBL1728538 | 0.68 | PTGS1 (0.73) | PTGS1PTGS2KDM4ERAB9ANPC1 | |
| SCHEMBL23728504 | 0.68 | PTGS1 (0.46) | PTGS1PTGS2KDM4EMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100004-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158634-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |