Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 1/20 | 0.56 |
| ▸ | NAAA | Q02083 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.45 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477552 | 0.98 | CASP2 (0.59) | CASP2NAAAKDM4ENPC1ALDH1A1 | |
| SCHEMBL24412633 | 0.93 | CASP2 (0.65) | CASP2NAAAKDM4EUSP2TP53 | |
| SCHEMBL24412952 | 0.93 | CASP2 (0.65) | CASP2NAAAKDM4EUSP2TP53 | |
| SCHEMBL24412969 | 0.92 | TP53 (0.51) | CASP2NAAAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL24412716 | 0.89 | CASP2 (0.59) | CASP2NAAAKDM4EALDH1A1TP53 | |
| SCHEMBL8437935 | 0.88 | FAAH (0.55) | CASP2NAAAKDM4ENPC1ALDH1A1 | |
| SCHEMBL20998566 | 0.87 | USP2 (0.56) | CASP2NAAAKDM4ENPC1ALDH1A1 | |
| SCHEMBL8124655 | 0.86 | PAOX (0.50) | CASP2KDM4ETP53SMN1; SMN2MAPT | |
| SCHEMBL17817099 | 0.86 | KDM4E (0.62) | CASP2NAAAKDM4EALDH1A1FAAH | |
| SCHEMBL15759109 | 0.85 | SMN1; SMN2 (0.50) | CASP2KDM4ENPC1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155321-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |