Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | UGT2B17 | O75795 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | INMT | O95050 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23729550 | 0.94 | HRH3 (0.42) | TNKSPARP1TNKS2GAAHRH3 | |
| SCHEMBL14585663 | 0.90 | TNKS (0.36) | TNKSPARP1TNKS2GAAHRH3 | |
| SCHEMBL15338767 | 0.74 | ALDH1A1 (0.40) | TNKSPARP1TNKS2GAAHRH3 | |
| SCHEMBL5994114 | 0.73 | NOTUM (0.51) | GAAALDH1A1MEN1MAPTHPGD | |
| SCHEMBL8276444 | 0.72 | NOTUM (0.50) | TNKSPARP1TNKS2GAAALDH1A1 | |
| SCHEMBL19908532 | 0.71 | HRH3 (0.37) | GAAHRH3ALDH1A1MEN1MAPT | |
| SCHEMBL2616323 | 0.71 | ALDH1A1 (0.60) | GAAALDH1A1MEN1MAPTHPGD | |
| SCHEMBL15628980 | 0.69 | ALDH1A1 (0.50) | TNKSPARP1TNKS2GAAALDH1A1 | |
| SCHEMBL20780397 | 0.69 | HRH3 (0.41) | TNKSPARP1TNKS2GAAHRH3 | |
| SCHEMBL22306946 | 0.69 | EZH2 (0.34) | GAAHRH3UGT2B17ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155321-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |