Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 8/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23730063 | 0.91 | MEN1 (0.36) | GNAI3GNAO1GNAI1NPC1SIGMAR1 | |
| SCHEMBL26700877 | 0.89 | NPC1 (0.38) | GNAI3GNAO1GNAI1NPC1SIGMAR1 | |
| SCHEMBL26700874 | 0.81 | KDM4E (0.34) | NPC1SIGMAR1KCNH2HRH3ALDH1A1 | |
| SCHEMBL22520624 | 0.81 | CACNA2D1 (0.43) | CACNA2D1CACNA1BCACNB1CACNA1CKCNH2 | |
| SCHEMBL26700788 | 0.79 | ALDH1A1 (0.39) | NPC1SIGMAR1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL27012385 | 0.78 | CACNA2D1 (0.43) | SIGMAR1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL27057099 | 0.77 | KDM4E (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CKCNH2 | |
| SCHEMBL26700931 | 0.77 | DRD2 (0.41) | GNAI3GNAO1GNAI1NPC1KCNH2 | |
| SCHEMBL23594438 | 0.75 | L3MBTL1 (0.44) | GNAI3GNAO1GNAI1KCNH2HRH3 | |
| SCHEMBL18705111 | 0.75 | HRH3 (0.48) | CACNA2D1CACNA1BCACNB1CACNA1CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348452-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-11-02 | — | — | US | disclosed |
| WO-2021155321-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348452-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, BRCA1 | GNAI3 2375/4885GNAO1 2529/4885GNAI1 2424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.